Current lab members
Lynne Cox (PI)
Adam Rolt (Elysium post-doctoral fellow)
Christopher Whiteman (DPhil student with Public Health England)
Thibault Teissier (BIRAX/Diabetes UK postdoctoral scientist)
Ivan Boubriak (UK SPINE postdoctoral scientist)
Loren Kell (Mellon Longevity Science Programme DPhil student)
Kara d'Arcy (Part II research project student)
Recent lab members
Hannah Walters (Humboldt post-doctoral fellowship, Dresden, Germany)
Sebastian Aguiar (Biotech startup on ageing, USA)
Hayley Lees (Clinical Geneticist, NHS)
Stephanie Gover (Medical School)
Lukeriya Zharova (DPhil student, London)
Strategy papers, evidence and policy:
- Linking interdisciplinary and multiscale approaches to improve healthspan—a new UK model for collaborative research networks in ageing biology and clinical translation (2022). Lynne S Cox and Richard G A Faragher. The Lancet Healthy Longevity, Volume 3, issue 5, E318-E320, May 01, 2022 DOI: https://doi.org/10.1016/S2666-7568(22)00095-2
- Tackling immunosenescence to improve COVID-19 outcomes and vaccine response in older adults (2020). Lynne S Cox, Ilaria Bellantuono, Janet M Lord, Elizabeth Sapey, Joan B Mannick, Linda Partridge, Adam L Gordon, Claire J Steves, Miles D Witham. The Lancet Healthy Longevity | VOLUME 1, ISSUE 2, E55-E57, NOVEMBER 01, 2020, DOI: https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(20)30011-8/fulltext
- "Health of the Nation: a Strategy for Healthier Longer Lives" report of the All Party Parliamentary Group for Longevity, launched 12th February 2020 Key chapter I (Lynne Cox): 'The Economic and Scientific Case for Therapeutic Intervention in Ageing' (https://appg-longevity.org/events-publications)
- Expert witness: House of Lords select committee Science and Technology Committee (Ageing: Science, Technology and Healthy Living):
Cox, LS.(Ed) (2009) Molecular Themes in DNA Replication. Royal Society of Chemistry (Cambridge) ISBN 978-0-85404-164-0 (research text)
Cox, LS, Harris, DA, Pears, CJ. (2012) Thrive in Biochemistry and Molecular Biology. OUP (Oxford). ISBN: 978-0-19-964548-0 (undergraduate teaching/revision text)
Research publications: (for further information on publications, awards, positions held etc, see https://orcid.org/0000-0002-5306-285X)
- Thibault Teissier, Vlasdislav Temkin, Rivka Dresner Pollak and Lynne S. Cox (2022). Crosstalk Between Senescent Bone Cells and the Bone Tissue Microenvironment Influences Bone Fragility During Chronological Age and in Diabetes. Front. Physiol., 21 March 2022 https://doi.org/10.3389/fphys.2022.812157
- Teissier T, Boulanger E and Cox LS (2022) Interconnections between inflammageing and immunosenescence during ageing. Cells 2022 11(3) 359; https://doi.org/10.3390/cells11030359https://www.preprints.org/manuscript/202110.0046/v1
- Lynne S Cox and Janet M Lord (2021) Coronavirus: Targeting aging cells improves survival. Science 16 Jul 2021: Vol. 373, Issue 6552, pp. 281-282 DOI: 10.1126/science.abi4474 https://science.sciencemag.org/content/373/6552/281.summary
- Walters, H and Cox, LS (2021) Intercellular transfer of mitochondria between senescent cells through cytoskeleton-supported intercellular bridges requires mTOR and Cdc42 signalling. Oxid Med and Cellular Longevity Vol 2021 Article ID 6697861, https://doi.org/10.1155/2021/6697861
- Rolt, AC and Cox, LS (2020) Structural basis of the anti-ageing effects of polyphenolics - mitigation of oxidative stress. BMC Chemistry volume 14, Article number: 50 (2020)
- Cox, LS. (2020) The Economic and Scientific Case for Therapeutic Intervention in Ageing. Key paper I (p72-80) in "Health of the Nation: a Strategy for Healthier Longer Lives", report of the APPG for Longevity, launched 12th February 2020, https://appg-longevity.org/events-publications
- Cox, L and Goljanek-Whysall, K (2019) Ageing here and now: current research and transformative therapies. Biogerontology 20: 249. https://doi.org/10.1007/s10522-019-09814-5
- Rolt, ACR, Nair, A and Cox, LS (2019) Optimisation of a screening platform for determining IL-6 associated inflammatory signalling in the senescence-associated secretory phenotype (SASP). Biogerontology https://doi.org/10.1007/s10522-019-09796-4
- Walters, HA and Cox, LS (2019) Generation of a novel model of primary human cell senescence through Tenovin-6 mediated inhibition of sirtuins. Biogerontology https://doi.org/10.1007/s10522-018-09792-0
- Walters, HW and Cox, LS (2018) mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases Int J Mol Sci. 2018 Aug 8;19(8). pii: E2325. doi: 10.3390/ijms19082325.
- Chennuri, P, Cox, LS and Saunders, RDC. (2018) EXD2 and WRN exonucleases are required for interstrand crosslink repair in Drosophila. Preprint doi: https://doi.org/10.1101/284307
- Cox, LS, Mason PA. (2018) Towards understanding the biological drivers of cell ageing. Chapter 8 in The New Dynamics of ageing, volume 2. Ed Walker, A. Policy Press (Bristol) ISBN 978-1-4473-1479-0.
- Latorre E, Birar VC, Sheerin AN, Jeynes JCC, Hooper A, Dawe HR, Melzer D, Cox LS, Faragher RGA, Ostler EL, Harries LW. (2017) Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence. BMC Cell Biol. 2017 Oct 17;18(1):31. doi: 10.1186/s12860-017-0147-7.
- Cox, LS and Redman C. (2017) The role of cellular senescence in ageing of the placenta Placenta. 2017 Apr;52:139-145. doi: 10.1016/j.placenta.2017.01.116. Epub 2017.
- Lees H, Walters H, Cox LS. (2016) Animal and human models to understand ageing. Maturitas. 2016 Nov;93:18-27. doi: 10.1016/j.maturitas.2016.06.008.
- Alimbetov D, Davis T, Brook AJ, Cox LS, Faragher RG, Nurgozhin T, Zhumadilov Z, Kipling D. (2016) Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2. Biogerontology. 2016 Apr;17(2):305-15. doi: 10.1007/s10522-015-9610-z.
- Walters HE, Deneka-Hannemann S, Cox LS. (2016) Reversal of phenotypes of cellular senescence by pan-mTOR inhibition. Aging (Albany NY). 2016 Feb;8(2):231-44.
UPCOMING: Ageing Biology subgroup of the European Geriatric Medicine Society (EuGMS) of which I am co-chair, will be launching at the forthcoming EuGMS 2020 E-Congress (https://eugms2020.online/) Wednesday Oct 7th , from 12.00 to 13.30 CEST.
24th September: Biochemical Society webinar: chairing the talk by Prof Alex Breeze, University of Leeds on "The biopharma drug development pathway: origins and comparison with small moelcule delivery"
Over the lockdown period and the summer of 2020, Lynne has given a number of online presenations including:
Oriel online (September 2020): How biomedical sceicens are central to tackling COVID- the role of Orielenses. In coversation with Prof Max Crispin, University of Southampton.
Clare College Cambridge digital gala week speaker June 2020
Oxford Healthy Ageing seminar series speaker 23rd June 2020: How to age well: lessons from geroscience
CogX speaker 9th June 2020
Longevity Leaders 2020 speaker 22nd May 2020: recorded panel discussion: Avoiding hype in ageing science
Also live session: Trends in Ageing Science
APPG for Longevity Roundtable 4 panellist 19th May 2020: a business index for health
Longevity Technology: Longevity week speaker 26th April 2020: Defining ageing
Oxford Business Network - virtual presentation at Babraham, Cambridge: How to age well: the potential of new drugs to improve health in later life
Schools Science Question Time: virtual presenation at Wimbledon College, London: Can we and should we interfere with the biology of ageing?
#OSEF2020: Oxford Said Entrepreneurship Forum: speaker at the Said Business Schools' annual flagship event, discussing "immortality"
Please note the planned Ageing Science seminar series for Trinity Term 2020 (https://www.archub.ox.ac.uk/2020/03/13/trinity-2020-seminar-series-pre-announcement/) has been postponed because of COVID-19. We hope to be able to run this exciting series of seminars by global leaders in the science of ageing in the future.
Healthy Ageing: From molecules to organisms: POSTPONED DUE TO COVID-19
27 - 29 May 2020 Wellcome Genome Campus, UK
The third conference in this series will focus on recent discoveries and current challenges in ageing research, with a focus on translating basic research insights into health improvement for older people.
Ageing can lead to declining health and function, and it is the major risk factor for cancer, neurodegenerative and cardiovascular disease. We aim to explore the mechanisms of ageing in cells, tissues and organisms in order to identify interventions that can ameliorate its negative effects.
The conference will focus on how recent developments in cell- and immune-senescence, neuroinflammation, stem cells and epigenetics are leading to an increased understanding of the ageing process. This year’s meeting will also highlight research into the ageing brain and nervous system and discuss lifestyle interventions for health improvement.
The meeting is aimed at scientists, clinicians and drug developers involved in research into ageing and other relevant fields.
What causes age-related disease and can ageing be treated?
Ageing and age-related diseases affect some people much more than others: there is no one fixed way to age and everyone is different. While we know that a good diet, exercise and plenty of sleep are important to maintain health, other factors out of our control (e.g. genes, environment) can lead to significant ill health and disability in later life. The vast majority of older people suffer from several chronic age-related diseases simultaneously - this is termed co-morbidity.
We now know that changes to cells as they age, termed cell senescence, can be critical in causing many different diseases of ageing. Exciting new research from labs around the world has shown that removing senescent cells can improve health in later life, and even extend lifespan in mice.
Cells undergo senescence in several different ways in response to DNA damage, activation of oncogenes or simply after they have undergone a large number of cell divisions until their telomeres (repetitive DNA structures at the ends of the chromosomes that shorten at every cell division cycle) have become critically short. Senescence is an important tumour suppressor mechanism to prevent damaged cells from dividing, but the many changes cells undergo as they become senescent leads to them altering their local environment, including degrading tissue structure and promoting a pro-inflammatory and pro-cancer environment.
By identifying the biochemical pathways and specific molecules involved, we aim to develop ways of altering the rate or outcomes of cell senescence, in order to better treat age-associated diseases and frailty.
"Health of the Nation: a Strategy for Healthier Longer Lives" report of the All Party Parliamentary Group for Longevity
launched 12th February 2020 with Rt Hon Matt Hancock, Secretary of State for Health and Social Care
see Key chapter I - Lynne Cox: 'The Economic and Scientific Case for Therapeutic Intervention in Ageing' (https://appg-longevity.org/events-publications)
The House of Lords Science and Technology Select Committee published on 15th January 2021 its in-depth report on 'Ageing: Science, Technology and Healthy Living' which makes very specific recommendations to the UK Government.
The following key findings are taken directly from the press release accompanying the report. I quote:
- New Science has potential to improve healthy ageing benefiting the individual, the NHS and society
- UK is global leader in drug development and new technologies with promising advances
- However, Government is missing its key healthy ageing targets and must act now
- Inequalities in healthy life expectancy are stark; COVID-19 has highlighted concerns
- Evidence that the rate of multi-morbidity is increasing; designated clinicians required
I provided both oral and written evidence to the committee which they refer to extensively in the report – a link to the report can be found here:
Further information from the House of Lords website about the enquiry is here.
Science Question Time on "Designing research to serve ageing populations" sponsored by MSD. The report (published 24th February 2021 and available here) highlights the importance of biomedical research in ageing, together with the need to include older people in clinical trials of therapies that will be of benefit to them.
Quote from the report:
"The COVID-19 pandemic has created unprecedented strain on health systems and societies around the world. It has shone a light on health inequalities and reinforced the importance of fostering health resilience. It has also highlighted the importance of scientific research to protect the health and wealth of societies. Science Question Time held on 25 November 2020 brought together leading scientists and policymakers to reflect upon these factors and think about the broader implications for R&D, asking the key question: ‘How can we design research to serve ageing populations and those with comorbidities, and ensure that research is reflecting our societal aim of achieving healthy longevity?’"
Talks, videos and podcasts:
BIRAX conference November 2021
As well as diseases traditionally associated with ageing, we are also looking at Type 1 diabetes as a model of premature ageing, studying whether cell senescence contributes to bone fragility and morbidity in diabetes. This is part of a collaboration under the BIRAX/British Council scheme with Prof Rivka Dresner-Pollak in Jerusalem, and funded by Diabetes UK. Here you can see the talk I gave at the latest BIRAX meeting on our progress (forgive the remote broadcasting issues with slide size) :
Longevity Forum Science Summit at Oriel College Oxford, 16th November 2021.
I was delighted to co-host this with Jim Mellon.
We were fortunate to hear from many eminent speakers and colleagues about recent advances in ageing science. Longevity Technology report back from the meeting - see:
Foresight Institute talk with Brian Kennedy and Joris Deelen, where I outline our ideas on the need for polypharmacology and systems biology thinking to address the complexity of ageing. Watch all three talks at: https://www.youtube.com/watch?v=VbWvH1qgcSs
International Longevity Policy and Governance - Lynne presented the case for biomedical longevity sciences helping in the fight against COVID
starts at 43:32 in : https://www.youtube.com/watch?v=xC2VivaPbp0&t=14s
UK SPINE conference: COVID-19 continues to impose a devastating burden on the global population, with older people most at risk of severe disease and death. It is vital that lessons from ageing biology are taken into account when designing new treatments and prophylaxis strategies, and that older people are included in clinical trials. See how basic research can lead to clinical trials in people:
"From bench to care home in a time of COVID"
Longevity Forum panel: How can the UK add five years of healthy lifespan by 2030?
Longevity Leaders #Ageing Science : Lynne is a Trend Host setting out where the field of biogerontology is moving - watch: https://www.youtube.com/watch?v=owi5u5t3Moo
Longevity Forum and The Big Middle podcast :